Clinical applications of antimicrobial photodynamic therapy in dentistry
Antimicrobial photodynamic therapy (aPDT) is emerging as a promising non-invasive treatment for oral infections. It has been effective against bacteria, fungi, and viruses, including pathogens like Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis. Advances in natural, nano-based, and targeted photosensitizers have enhanced its efficacy. Clinical studies, crucial for evidence-based applications, have shown aPDT to be effective in reducing pathogenic bacterial loads in periodontal, peri-implant, and persistent endodontic infections. However, more randomized clinical trials are needed to determine optimal protocols and parameters. Further high-quality trials with specific photosensitizers and irradiation parameters are essential for establishing effective clinical practices.
